RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-33
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
Echocardiography; PCR etc.
Target
LIPID RAFT
Pathway
PI3K-AKT SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart byPreserving Lipid Raft Cholesterol
Year
2017
Function
"Deficiency of miR-33 impaired cardiac fibroblast proliferation, which was considered to be caused by altered lipid raft cholesterol content. miR-33 is involved in cardiac remodeling, and it preserves lipid raft cholesterol content in fibroblasts and maintains adaptive fibrotic responses in the remodeling heart."